Table 2.
List of the top 30 downregulated genes in Jagged1 treated hDPs compared with the control cells.
| Gene | Locus | Name | Entrez Gene | Log2 (Ratio) | q value |
|---|---|---|---|---|---|
| HEATR6 | chr17:60041365-60078931 | HEAT repeat containing 6 | 63897 | −5.76 | 8.96E-04 |
| MIR4737 | microRNA4737 | 100616210 | |||
| DKK2 | chr4:106921801-107283784 | Dickkopf 2 homolog | 27123 | −5.04 | 3.10E-03 |
| SOST | chr17:43753730-43758788 | Sclerostin | 50964 | −4.24 | 1.42E-02 |
| C4orf22 | chr4:80266334-80963756 | Chromosome 4 open reading frame 22 | 255119 | −3.97 | 8.96E-04 |
| FGF5 | Fibroblast growth factor 5 | 2250 | |||
| MYPN | chr10:68105890-68212016 | Myopalladin | 84665 | −3.88 | 8.96E-04 |
| TNFRSF11B | chr8:118923556-118952144 | Tumor necrosis factor receptor superfamily, member 11b | 4982 | −3.76 | 8.96E-04 |
| SDPR | chr2:191834305-191847280 | Serum deprivation response | 8436 | −3.58 | 5.62E-03 |
| NOG | chr17:56593698-56595590 | Noggin | 9241 | −3.36 | 8.96E-04 |
| NEFM | chr8:24913760-24919093 | Meurofilament, medium polypeptide | 4741 | −3.19 | 8.96E-04 |
| KRT19 | chr17:41523616-41528389 | Keratin 19 | 3880 | −3.03 | 8.96E-04 |
| BIRC3 | chr11:102317449-102339403 | Baculoviral IAP repeat containing 3 | 330 | −3.02 | 8.96E-04 |
| RGCC | chr13:41457405-41470877 | Regulatory of cell cycle | 28984 | −3 | 8.96E-04 |
| ZNF367 | chr9:96385942-96418387 | Zinc finger protein 367 | 195828 | −2.98 | 8.96E-04 |
| ANXA3 | chr4:78551587-78610451 | Annexin A3 | 306 | −2.96 | 8.96E-04 |
| FAM111B | chr11:59107184-59155038 | Family with sequence similarity 111, member B | 374393 | −2.82 | 1.57E-02 |
| OXTR | chr3:8750408-8769614 | Oxytocin receptor | 5021 | −2.82 | 8.96E-04 |
| SLC14A1 | chr18:45724122-45752520 | Solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 6563 | −2.81 | 8.96E-04 |
| LPAR3 | chr1:84811603-84893213 | Lysophosphatidic acid receptor 3 | 23566 | −2.71 | 8.96E-04 |
| CDCP1 | chr3:45082273-45146422 | CUB domain containing protein 1 | 64866 | −2.6 | 8.96E-04 |
| LRRC2 | chr3:46515387-46566550 | Leucine rich repeat containing 2 | 79442 | −2.59 | 8.96E-04 |
| KRTAP1-1 | chr17:41025938-41168172 | Keratin associated protein 1-1 | 81851 | −2.55 | 8.96E-04 |
| KRTAP1-3 | Keratin associated protein 1-3 | 81850 | |||
| KRTAP1-5 | Keratin associated protein 1-5 | 83895 | |||
| KRTAP4-3 | Keratin associated protein 4-3 | 85290 | |||
| KRTAP4-5 | Keratin associated protein 4-5 | 85289 | |||
| KRTAP4-6 | Keratin associated protein 4-6 | 81871 | |||
| KRTAP4-8 | Keratin associated protein 4-8 | 728224 | |||
| KRTAP9-7 | Keratin associated protein 9-7 | 100505724 | |||
| TOX | chr8:58805417-59119208 | Thymocyte selection-associated high mobility group box | 9760 | −2.54 | 1.69E-03 |
| TCF21 | chr6:133889120-133895537 | Transcriptional factor 21 | 6943 | −2.48 | 3.78E-03 |
| CNIH3 | chr1:224616363-224740547 | Cornichom homolog 3 (Drosophila) | 149111 | −2.47 | 8.96E-04 |
| TPD52L1 | chr6:125153728-125263498 | Tumor protein D52-like 1 | 7164 | −2.45 | 8.96E-04 |
| E2F2 | chr1:23506427-23531220 | E2F transcription factor 2 | 1870 | −2.4 | 3.10E-03 |
| ANO1 | chr11:69985865-70189546 | Anoctamin 1, calcium activated chloride channel | 55107 | −2.39 | 8.96E-04 |
| LRRN3 | chr7:110663049-111562517 | Leucine rich repeat neuronal 3 | 54674 | −2.38 | 4.46E-02 |
| MET | chr7:116672404-116798386 | Met proto-oncogene (hepatocyte growth factor receptor) | 4233 | −2.38 | 8.96E-04 |
| EDNRB | chr13:77818936-77975529 | Endothelin receptor type B | 1910 | −2.32 | 8.96E-04 |