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. 2017 Aug 31;7:10167. doi: 10.1038/s41598-017-10862-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Response of MOR161-2 to acetophenone and methyl salicylate. (A) Comparison of the responses of MOR161-2 to acetophenone and methyl salicylate in the presence or absence of CYP1a2. The statistical significance was assessed using a t test (*P < 0.05, **P < 0.01). (B) Response of MOR161-2 to the mixture of acetophenone and methyl salicylate. E.g. 25:75 designates the mixture of 25% of 100 µM of acetophenone and 75% of 100 µM of methyl salicylate. The response was analyzed using the Dual-Glo luciferase assay system as described in the Materials and Methods. The relative response of ORs was calculated as (Luc/RL)/(Luc/RL without odorant solution).