Table 4.
Clinical and physiological characteristics of patients with hyperglycaemia, hypoglycaemia, and excessive glycaemic variability among patients with C-CH.
| C-CH | Hyperglycaemia | Hypoglycaemia | Excessive glycaemic variability | ||||||
|---|---|---|---|---|---|---|---|---|---|
| (+) | (−) | P value | (+) | (−) | P value | (+) | (−) | P value | |
| Gender (F/M) | 11/18 | 6/5 | ns | 4/2 | 13/21 | ns | 8/16 | 9/7 | ns |
| Age (yo) | 69.6 ± 9.2 | 69.2 ± 10.3 | ns | 73.8 ± 6.7 | 68.7 ± 9.7 | ns | 71.3 ± 8.0 | 66.7 ± 10.8 | ns |
| BMI (Kg/m2) | 23.6 ± 2.8 | 25.1 ± 5.3 | ns | 25.3 ± 4.4 | 23.8 ± 3.6 | ns | 23.5 ± 2.9 | 24.8 ± 4.6 | ns |
| FBS (mg/dl) | 119.2 ± 46.7 | 98.1 ± 17.8 | ns | 87.0 ± 4.8 | 118.1 ± 43.8 | ns | 114.7 ± 44.5 | 111.5 ± 37.6 | ns |
| f-IRI (μU/ml) | 11.8 ± 7.5 | 9.3 ± 4.2 | ns | 10.5 ± 6.3 | 11.3 ± 7.0 | ns | 11.5 ± 7.6 | 10.6 ± 5.6 | ns |
| HOMA-IR | 3.50 ± 2.40 | 2.29 ± 1.22 | ns | 2.24 ± 1.31 | 3.38 ± 2.32 | ns | 3.35 ± 2.54 | 2.94 ± 1.63 | ns |
| HbA1c (%) | 6.5 ± 1.3 | 5.6 ± 1.1 | ns | 5.2 ± 0.5 | 6.5 ± 1.3 | <0.05 | 6.6 ± 1.3 | 5.8 ± 1.1 | ns |
| 1,5-AG (μg/ml) | 13.5 ± 9.3 | 30.2 ± 4.6 | <0.05 | 16.9 ± 10.5 | 15.2 ± 10.3 | ns | 13.3 ± 8.4 | 20.6 ± 12.6 | ns |
| AST (IU/L) | 57.3 ± 27.1 | 51.7 ± 22.1 | ns | 60.7 ± 31.3 | 54.9 ± 24.8 | ns | 59.5 ± 28.3 | 50.2 ± 20.8 | ns |
| ALT (IU/L) | 43.9 ± 24.2 | 43.1 ± 19.2 | ns | 32.5 ± 11.3 | 45.6 ± 23.9 | ns | 46.3 ± 25.6 | 39.7 ± 17.5 | ns |
| ALP (IU/L) | 380.5 ± 164.1 | 409.1 ± 158.3 | ns | 362.2 ± 160.9 | 391.6 ± 163.1 | ns | 360.6 ± 160.8 | 431.5 ± 157.2 | ns |
| GGT (IU/L) | 65.8 ± 48.2 | 74.8 ± 120.9 | ns | 97.8 ± 159.4 | 63.0 ± 45.5 | ns | 72.8 ± 50.1 | 61.5 ± 102.3 | ns |
| T-Bil (mg/dl) | 1.11 ± 0.97 | 0.87 ± 0.38 | ns | 0.96 ± 0.43 | 1.06 ± 0.91 | ns | 0.88 ± 0.36 | 1.30 ± 1.24 | ns |
| TP (g/dl) | 7.0 ± 0.7 | 7.6 ± 0.6 | <0.05 | 7.5 ± 1.0 | 7.1 ± 0.6 | ns | 7.0 ± 0.7 | 7.4 ± 0.6 | <0.05 |
| ALB (g/dl) | 3.3 ± 0.7 | 4.1 ± 0.5 | <0.005 | 3.6 ± 0.6 | 3.5 ± 0.8 | ns | 3.3 ± 0.8 | 3.8 ± 0.6 | <0.05 |
| T-CHO (mg/dl) | 141.2 ± 29.6 | 171.2 ± 31.7 | <0.05 | 156.0 ± 20.7 | 148.7 ± 34.8 | ns | 140.4 ± 26.0 | 162.9 ± 37.1 | <0.05 |
| TG (mg/dl) | 98.1 ± 43.8 | 118.4 ± 61.5 | ns | 94.3 ± 22.4 | 104.8 ± 52.3 | ns | 103.6 ± 44.5 | 103.8 ± 56.3 | ns |
| RBC (×104/μl) | 376.9 ± 51.6 | 403.7 ± 56.0 | ns | 350.8 ± 20.8 | 390.2 ± 56.1 | ns | 381.1 ± 46.1 | 389.1 ± 64.2 | ns |
| Hb (g/dl) | 12.2 ± 1.7 | 13.0 ± 1.5 | ns | 11.3 ± 0.8 | 12.6 ± 1.7 | ns | 12.4 ± 1.6 | 12.5 ± 1.8 | ns |
| PLT (×104/μl) | 11.8 ± 7.0 | 15.5 ± 4.7 | ns | 13.4 ± 5.4 | 12.7 ± 6.8 | ns | 12.8 ± 7.1 | 12.9 ± 5.9 | ns |
| WBC (×103/μl) | 4.8 ± 2.0 | 5.6 ± 1.9 | ns | 4.3 ± 1.3 | 5.1 ± 2.1 | ns | 5.0 ± 2.1 | 5.0 ± 2.0 | ns |
| IV collagen 7S (ng/ml) | 9.6 ± 3.8 | 6.9 ± 2.7 | ns | 8.0 ± 2.0 | 9.0 ± 4.0 | ns | 9.1 ± 3.2 | 8.4 ± 4.2 | ns |
| P-3-P (U/ml) | 1.2 ± 0.3 | 1.1 ± 0.1 | ns | 1.2 ± 0.1 | 1.2 ± 0.3 | ns | 1.2 ± 0.3 | 1.2 ± 0.2 | ns |
| FIB-4 index | 7.52 ± 6.15 | 4.40 ± 2.79 | ns | 7.15 ± 5.44 | 6.58 ± 5.64 | ns | 6.69 ± 4.36 | 6.63 ± 7.08 | ns |
| PT (INR) | 1.17 ± 0.23 | 1.12 ± 0.16 | ns | 1.22 ± 0.22 | 1.15 ± 0.21 | ns | 1.14 ± 0.16 | 1.18 ± 0.28 | ns |
Hyperglycaemia: maximum blood glucose of ≥80 mg/dl; hypoglycaemia: minimum blood glucose of <70 mg/dl; excessive glycaemic variability: blood glucose swings of ≥110 mg/dl.