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. 2017 Aug 31;7:10227. doi: 10.1038/s41598-017-09191-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Habituation of sham-irradiated and proton-irradiated mice at the 20-week time point. There was an effect of day (F = 75.22, p < 0.0001), indicating that both groups habituated to the open field. ^# p < 0.0001 versus days 2 and 3. (B) Object recognition at the 2-week time point. Sham-irradiated showed object recognition and spent significantly more time exploring the novel than the familiar object. In contrast, irradiated mice did not. N = 16 mice/dose. *p < 0.05.