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. 2017 Aug 31;7:10227. doi: 10.1038/s41598-017-09191-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A comparable total number of Arc-positive neurons in the CA1 (A) and CA3 (B) regions of the hippocampus at the 2-week time point. The percentage of Arc-positive neurons in the CA1 region of the hippocampus at the 2-week time point. (C) The percentage of Arc-positive neurons in the CA1 region of the hippocampus of sham-irradiated mice was higher following exposure to twice the same environment than two different environments. This was not seen in irradiated mice. (D) There was a trend towards a higher percentage of Arc-positive neurons expressing Arc mRNA in the nucleus and cytoplasm in the CA3 region of the hippocampus following exposure twice to the same environment, as opposed to exposure to two different environments in sham-irradiated mice but that did not reach significance. *p < 0.05 versus same environment; ^# p = 0.0578. N = 5–7 mice/dose/environment.