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. 2017 Aug 31;7:10227. doi: 10.1038/s41598-017-09191-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene ontology analyses of upregulated 5hmC DHRs (A) and downregulated DHRs. (B) DHRs were annotated with the closest RefSeq gene start site within 50 kb. (C) Selected genes from the synapse gene ontology category. Green depicts genes found in upregulated DHRs, red depicts genes found in down-regulated DHRs and blue depicts genes found in both categories. (D) KEGG pathway analysis shows that up and down-regulated DHRs are both enriched for the same set of LTP-associated genes. p < 1 × 10⁻⁶. The KEGG database was developed by the Kanehissa Laboratories, as described⁷⁵.