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. 2017 Aug 7;85(1):8–13. doi: 10.1007/s00239-017-9804-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The Central Dogma describes the flow of information in biological systems. The black arrows are allowed processes. The red arrows are not observed. “Once information has got into a protein it can’t get out again” (Crick 1958) (Color figure online)