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. 2017 Mar 14;27(10):4019–4029. doi: 10.1007/s00330-017-4767-2

Table 1.

Overview of nodule management scoring system categories and corresponding criteria

Scoring system Category Criteria Management
PanCan 1 Normal finding, nodule risk index <1.5% Biennial LDCT screening
2 Low-risk of malignancy: nodule risk index 1.5% – <6% Annual LDCT screening
3 Moderate risk of malignancy: nodule risk index 6% – <30% 3-month LDCT
4 High-risk of malignancy: nodule risk index ≥30% Direct referral
Lung-RADS (version 1.0) 1 No nodules, or nodules with complete, central, popcorn, or concentric rings of calcification, fat containing nodules Annual LDCT screening
2 Solid nodules < 6 mm
Part-solid nodules <6 mm in total diameter
Pure ground-glass nodules <20 mm
Annual LDCT screening
3 Solid nodules ≥ 6 – <8 mm
Part-solid nodules ≥ 6 mm in total diameter with solid component < 6 mm
Pure ground-glass nodules ≥20 mm
6-month LDCT
4A Solid nodules ≥ 8 – < 15 mm
Part-solid nodules ≥6 mm with solid component ≥6 – <8 mm
3-month LDCT; PET/CT
4B Solid nodules ≥ 15 mm
Part-solid nodules with a solid component ≥ 8 mm
Chest CT with/without contrast, PET/CT and/or tissue sampling
NCCN (version 1.2016) 1 Solid nodule or part-solid nodule < 6 mm Annual LDCT for 2 years
2 Pure ground-glass nodule ≤ 5 mm
Multiple pure ground-glass nodules ≤ 5 mm
LDCT in 12 months
3 Pure ground-glass nodule > 5-10 mm
Multiple pure ground-glass nodules with a diameter >5 mm without a dominant lesion
LDCT in 6 months
4 Pure ground-glass nodule > 10 mm
Multiple pure ground-glass nodules with a dominant nodule(s) with a solid component
LDCT in 3–6 months
5 Solid nodule or part-solid nodule 6–8 mm LDCT in 3 months
6 Solid nodule or part-solid nodule > 8 mm Consider PET/CT

LDCT low-dose CT