Table 1.

Overview of nodule management scoring system categories and corresponding criteria

Scoring system	Category	Criteria	Management
PanCan	1	Normal finding, nodule risk index <1.5%	Biennial LDCT screening
	2	Low-risk of malignancy: nodule risk index 1.5% – <6%	Annual LDCT screening
	3	Moderate risk of malignancy: nodule risk index 6% – <30%	3-month LDCT
	4	High-risk of malignancy: nodule risk index ≥30%	Direct referral
Lung-RADS (version 1.0)	1	No nodules, or nodules with complete, central, popcorn, or concentric rings of calcification, fat containing nodules	Annual LDCT screening
	2	Solid nodules < 6 mm Part-solid nodules <6 mm in total diameter Pure ground-glass nodules <20 mm	Annual LDCT screening
	3	Solid nodules ≥ 6 – <8 mm Part-solid nodules ≥ 6 mm in total diameter with solid component < 6 mm Pure ground-glass nodules ≥20 mm	6-month LDCT
	4A	Solid nodules ≥ 8 – < 15 mm Part-solid nodules ≥6 mm with solid component ≥6 – <8 mm	3-month LDCT; PET/CT
	4B	Solid nodules ≥ 15 mm Part-solid nodules with a solid component ≥ 8 mm	Chest CT with/without contrast, PET/CT and/or tissue sampling
NCCN (version 1.2016)	1	Solid nodule or part-solid nodule < 6 mm	Annual LDCT for 2 years
	2	Pure ground-glass nodule ≤ 5 mm Multiple pure ground-glass nodules ≤ 5 mm	LDCT in 12 months
	3	Pure ground-glass nodule > 5-10 mm Multiple pure ground-glass nodules with a diameter >5 mm without a dominant lesion	LDCT in 6 months
	4	Pure ground-glass nodule > 10 mm Multiple pure ground-glass nodules with a dominant nodule(s) with a solid component	LDCT in 3–6 months
	5	Solid nodule or part-solid nodule 6–8 mm	LDCT in 3 months
	6	Solid nodule or part-solid nodule > 8 mm	Consider PET/CT

LDCT low-dose CT