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. 2017 Aug 31;7:10134. doi: 10.1038/s41598-017-09452-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PEDF−/− BM cells give rise to stable reconstitution and normal hematopoiesis in competitive transplantation experiments. (A) Engraftment in primary recipients measured by flow cytometric analysis of engrafted CD45.2⁺ donor cells in recipient PB at four weeks. (B) Lineage distribution of CD45.2⁺ cells in PB at four weeks time point, myeloid cells: Mac/Gr, B-cells: B220 and T-cells: CD3. (C) Engraftment in BM of primary transplanted recipients 20 weeks post transplantation. (D) Lineage distribution 20 weeks post transplantation in BM of primary transplanted mice. (E) Flow cytometric analysis of LSKCD48⁻CD150⁺ cell and LSK cell frequencies in BM of primary recipients. Data are mean or shows individual mice (C and E) from three independent experiments ± SEM, n = 3 donors per genotype and 2–3 recipients per donor.