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. 2017 Aug 31;7:10142. doi: 10.1038/s41598-017-10486-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic of the synthesis route of Rhodamine-doped silica nanoparticles, TRA-imprinted Rhodamine-doped silica artificial antibody, and the scheme to illustrate the interaction between TRA-imprinted artificial antibody and cancer cells; (b) Schematic of the application of the artificial antibody for CTCs.