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. 2017 Aug 31;7:10142. doi: 10.1038/s41598-017-10486-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The fluorescence images of TRA-imprinted artificial antibody for targeting and labeling the CTCs in mimetic CTCs model. (a–d) nuclear staining with Hoechst, respectively; (e–h) artificial antibody-loaded cells, respectively; (i–l) merged image of (a,e,b,f,c,g,d,h), respectively. Four sets of parallel experiments were employed. The white blood cells are marked in red circles. The concentration of the artificial antibody is 10 μg/mL.