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. 2017 Aug 31;7:10252. doi: 10.1038/s41598-017-10928-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Experimental Strategy: 1. Cox 2 inhibitors (coxibs) are known to increase coronary risk. 2. All genes known to be targets of coxibs were extracted from the Drug-Gene Interaction Database (DGIdb). 3. DGIdb revealed 47 genes that interact with coxibs. 4. All common variants at the chromosomal regions representing the 47 genes were subjected to a large-scale association study. 5. Four genes displayed significance for association with CAD risk. 6. These genes are candidate risk genes for CAD. 7. It may be hypothesized that the genes affected by coxibs and here shown to associate with CAD risk participate in the adverse effects of the drugs. Some drawings were obtained and used under license from Shutterstock.com (https://www.iconfinder.com/licenses/basic). Images can be found under: https://www.shutterstock.com/image-vector/chromosomes-vector-icon-style-flat-symbol-323629910?src=library, https://www.shutterstock.com/image-vector/organ-heart-icon-310580756, https://www.shutterstock.com/image-vector/dna-icon-397249525, https://www.shutterstock.com/image-vector/pills-medication-vector-icons-set-131402543?src=library, https://www.iconfinder.com/icons/240302/find_computer_find_desktop_look_for_desktop_search_search_desktop_icon#size=128.