Table 1.

Association signals for CAD within 200 kb of genes reported for coxib/gene product interactions.

Gene	Lead SNP	CAD risk allele	Frequency risk allele	OR risk allele	P-value	P-value combined analysis	Relationship of coxib to gene/gene product*	Regulatory effect (Histone marks)
BCAR1	rs4888383	T	0.57	1.05	7.99*10−08	2.98*10−08	inhibition	Promoter/Enhancer
MMP9	rs7270354	A	0.15	1.06	6.75*10−08	3.34*10−08	decreased expression	Promoter/Enhancer
VEGFA	rs6905288	A	0.60	1.04	7.44*10−07	8.86*10−07	decreased expression	Enhancer
CACNA1E	rs556321	C	0.16	1.05	8.26*10−06	8.85*10−06	inhibition	Promoter/Enhancer

For each gene, the lead SNP is shown. The regulatory effects were annotated using Haploreg²⁵.