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. 2017 Aug 31;7:10164. doi: 10.1038/s41598-017-10755-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Health score. Two groups of mice (n = 6 per group) were pre-treated i.p. with 5 µg LysEF-P10. When the titre of anti-LysEF-P10 reached its peak, the mice were treated i.p. with 5 mg LysEF-P10 or an equivalent quantity of buffer. The health status of the mice was scored on a scale of 0 to 5 at 10 d after treatment. A score of 5 indicates normal health and an unremarkable condition. Slight illness was defined as decreased physical activity and ruffled fur and was scored as 4. Moderate illness was defined as lethargy and a hunched back and was scored as 3. Severe illness was defined as the aforementioned signs plus exudative accumulation around partially closed eyes and was scored as 2. A moribund state was scored as 1. Death was scored as 0. Each dot indicates the health status of a single mouse. N.S., not significant.