Figure 3. Proteolytic processing of APP in wild‐type and Tg mice.

(A) APP processing by β‐secretase, α‐secretase, and η‐secretase pathways, respectively. (B) Western blot analysis of APP and APP‐derived fragments in wild‐type (WT), App ^NL‐F , and APP23 mice indicated that only APP23 mice produced APP and non‐Aβ APP fragments in substantial abundance. App ^NL‐F mice overproduce CTFβ; however, App ^NL mice produce the same amount without Aβ deposition (Saito et al, 2014), therefore serving as relevant negative controls. (C) Proteins that are overproduced in APP‐overexpressing mice.