Figure 6. Superposition of RNA helices with potential trans sugar‐Hoogsteen G·A pairs (PDB 5LR3 and 5LR4), with and without N⁶‐methylation of adenine.

The unmethylated structure is shown (green) and the methylated structure (pink). Images are shown as parallel‐eye stereoscopic pairs.

1. Stereo image of superimposed structures, showing the central G·A pairs and flanking G‐U base pairs.
2. Superimposed view of one of the G·A pairs. Note that the G·N⁶mA base pair is disrupted, such that the N⁶‐methyladenine is significantly translated away from the opposing guanine base. The RMSD for the four G, A nucleotides is 0.962 Å.