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. 2017 Aug 9;18(9):1646–1659. doi: 10.15252/embr.201643581

Figure EV5. Over‐expression of circHIPK3 down‐regulates the expression of HPSE, MMP‐9, and VEGF in bladder cancer cells.

Figure EV5

  • A–D
    Real‐time PCR and Western blot assays demonstrated that over‐expression of circHIPK3 in bladder cancer cells significantly down‐regulates the expression of HPSE, together with its downstream targets MMP‐9 and VEGF. In contrast, knockdown of circHIPK3 up‐regulates the expression of HPSE, MMP‐9, and VEGF. Data are mean ± SEM, n = 3. **P < 0.01 versus vector (A) or si NC (B) (Student's t‐test).