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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Crit Care Med. 2014 Oct;42(10):2278–2289. doi: 10.1097/CCM.0000000000000504

Figure 2.

Figure 2

Mean tidal volume (VT) for the various types of centers and trials are shown. The area of each circle is proportional to the inverse of the variance associated with each mean VT value. The solid diagonal line in each panel represents the weighted regression line and the dashed lines represent the 95% CIs for the relationship between baseline VT and the date of initial enrollment into trials in each group. Equations for the weighted regression lines and p-values for the slope of the line are shown for each group of studies. A horizontal line denoting a 6 mL/kg PBW VT is shown in each panel for reference to the VT targeted in the ARDSNet LVT protocol. Panels E and F show data post-randomization VT in RCTs employing low VT protocols.