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. 2017 Aug 4;49(8):e362. doi: 10.1038/emm.2017.107

Figure 2.

Figure 2

dNP2-ctCTLA-4 ameliorates airway hyper-responsiveness induced by German cockroach extract (GCE). (a) Eight-week-old BALB/c mice were intranasally administered 120 μg of GCE twice per week for 3 weeks and 10 μg of dNP2-ctCTLA-4, dNP2-EGFP or PBS was intranasally co-administered. (b, c) Airway hyper-responsiveness was analyzed by a flexiVent 5.1 small animal ventilator. (b) Airway resistance was measured with increasing doses of methacholine (MeCh). (c) Airway elastance was measured with increasing doses of MeCh. n=5 per group, and results are presented as the mean±s.e.m. ***P<0.001.