Figure 7.

CHOP and UPR caspase cascade are activated in older TauTKO hearts. Total heart lysates from 12-month-old TauTKO and WT mouse hearts were subjected to western blot analysis of (A) CHOP, (B) caspase 12, (C) caspase 3 and (D) PARP. Each panel contains a representative gel and summation data expressed as means ± SEM of 6–9 hearts. The representative bands for WT and TauTKO shown in B were spliced from one original gel and the splice junction is indicated by the black splicing line. All values are expressed relative to WT, where WT is fixed at 1.0. * p < 0.05.