Table 3.
Gene fusions selected for validation
| Fusion | Intra chrom | Donor gene | Gene expression log fold change | Acceptor gene | Gene expression log fold change | TCGA overlap | # tumors | Validated |
|---|---|---|---|---|---|---|---|---|
| chr3~chr3:100438902-100348442 | N | TFG | 0.243 | GPR128 | 9.97 | Y | 3 | Y |
| chr4~chr4:1808661-1741429 | N | FGFR3 | 2.61 | TACC3 | 1.39 | Y | 1 | Y |
| chr17~chr17:80797803-80828100 | N | ZNF750 | −5.13 | TCBD | 1.82 | Y | 1 | N |
| chr20~chr2:48330113-212812341 | Y | B4GALT5 | 0.71 | ERBB4 | 5.82 | N | 1 | Y |
| chr10~chr10:89653866-90347023 | N | PTEN | −1.85 | LIPJ | 7.38 | N | 1 | Y |
| chr20~chr20:32581937-41199932 | N | RALY | 1.94 | PTPRT | −5.78 | N | 1 | Y |
BOLD indicates statistically significant gene expression change.
Intrachrom indicates gene fusion spanning across different chromosomes. Gene expression log fold change (between tumors harboring a fusion and normal tissue) is shown for both donor and acceptor genes.