Table 1.
Examples of drugs for treating neuropsychiatric disorders, and their respective protein targets.
| Drug | For treating: | Main putative site(s) of action | Type |
|---|---|---|---|
| Alprazolam | Anxiety, Panic disorder | GABAA Receptor (Bz binding site) | Channel |
| Amphetamine | ADHD, Narcolepsy | DAT | Transporter |
| Ariprazole | Psychosis, Depression | D2, 5-HT1A and other receptors | GPCRs |
| Buprenorphine | Opiate addiction, Pain | μ-Opiate receptor | GPCR |
| Duloxetine | Depression, Anxiety | SERT and NET | Transporters |
| Escitalopram | Depression, Anxiety | SERT | Transporter |
| Fluoxetine | Depression, Anxiety | SERT | Transporter |
| Galantamine | Alzheimer’s disease | AChE | Enzyme |
| Lorazepam | Anxiety, Panic disorder | GABAA receptor (Bz binding site) | Channel |
| Memantine | Alzheimer’s disease | NMDA Receptor | Channel |
| Methylphenidate | ADHD | DAT | Transporter |
| Pregabalin | Neuropathic pain, Anxiety | Ca2+ channel (α2δ subunit) | Channel |
| Quetiapine | Bipolar disorder, Schizophrenia | D2, 5-HT2A Receptors, and others | GPCRs |
| Rasagiline | Parkinson’s disease | MAO-B | Enzyme |
| Risperidone | Schizophrenia, Bipolar disorder | D2 and 5-HT2 receptors | GPCRs |
| Sertraline | Depression, Anxiety, OCD, PTSD, PMDD | SERT | Transporter |
| Trazodone | Depression, Anxiety | SERT | Transporter |
| Venlafaxine | Depression, Anxiety | SERT, NET and DAT | Transporters |