Table 3.
Examples of PET studies determining brain protein density (Bavail) and/or radioligand (KD) affinity in normal human subjects, and the corresponding Bavail/KD values.
| Protein | Brain region | Radioligand | Bavail from PET (nM) | KD from PET (nM) | Bavail/KD from PETa | Reference |
|---|---|---|---|---|---|---|
|
| ||||||
| Bz | R. m. t. ctx Occ. ctx. | [11C]Flumazenil | 55±12 | 12±2 | 5 | [34] |
| [11C]Flumazenil | 89 | 13.7 | 7 | [94] | ||
|
| ||||||
| D1 | R. caudate | [11C]SCH23390 | 45±12 | 22±8 | 2 | [95] |
|
| ||||||
| D2 | Putamen | [11C]Raclopride | 14±2 | 3.8±0.6 | 4 | [32] |
| R. putamen Striatum | [11C]Raclopride | 28± 8 | 9±2 | 3 | [96] | |
| [11C]Raclopride | 29±4 | 9±1 | 3 | [97] | ||
|
| ||||||
| D2 | Thalamus | [11C]FLB-457 | 2.3±0.6 | 0.7±0.3 | 3 | [98] |
|
| ||||||
| Opiate | Thalamus | [11C]Diprenorphine | 19±2 | 0.7±0.2 | 25 | [33] |
a
Rounded to nearest integer.