Table 7.

Examples of labeled sub-structures found in ¹⁸F-Labeled PET radioligands studied in humans, and whether noted to be susceptible to radiodefluorination.

Entry	Labeled sub-structure	Radioligand examples	Noted defluorination susceptibility	References
1		[18F]Flumazenil	No	[239]
2		[18F]Flumetamol	No	[247]
3		p-[18F]MPPF	No	[248]
4		[18F]FIMX	No	[228]
5		[18F]Altanserin	No	[249]
6		[18F]FPEB	No	[250]
7		2-[18F]F-A85380	No	[251] [252]
8		[18F]MK-6577	No, but some skull radioactivity uptake	[253]
9		[18F]AZAN	No	[254]
10		[18F]T807	Negligible	[255]
11		[18F](-)-Flubatine	Negligible	[256]
12		6-[18F]F-A85380	No	[257]
13		[18F]UCB-H	No	[258]
14		[18F]SP203	Low, but radioactivity uptake in red marrow	[259]
15		[18F]Fallypride	No	[260]
16		[18F]FMPEP-d2	Yes	[140]
17		[18F]FMENER-d2	Yes	[261]
18		[18F]SPA-RQ	Low, but some radioactivity uptake in red marrow	[262]
19		[18F]Fluoromethyl-McN5652	No	[263]
20		[18F]DPA-714	No but some skull radioactivity uptake - presumed to be in marrow	[264]
21		[18F]MNI-659	No but some skull radioactivity uptake - presumed to be in marrow	[265]
22		[18F]MNI-444	No, but low skull radioactivity up-take	[266]
23		[18F]MK-9470	No	[267]
24		[18F]FEOBV	No	[268]
25		[18F]FEPPA	No	[269]
26		[18F]THK-523	No, but low radioactivity uptake in skull	[270]
27		[18F]FESPA-RQ	Yes, but low	[271]
28		[18F]FEDAA1106	No	[272]
29		[18F]FACT	No, but low radioactivity uptake in skull	[273]
30		[18F]AV45	No	[274]
31		[18F]FP-(+)-DTBZ ([18F]AV-133)	No	[275]
32		Trans-[18F]FCWAY	Yes	[276]
33		[18F]Mefway	No	[277]
34		[18F]FBR	Negligible	[278]
35		[18F]FECNT	No	[167] [279]
36		[18F]JNJ42259152	No	[280]
37		[18F]CPFPX	No	[281]
38		[18F]FPCIT	No	[282]
39		[18F]LBT-999	Yes	[283]