Table 1.
Baseline characteristics of a multi-ethnic, asymptomatic cohort according to family history of premature coronary disease status.
| Negative FH (n= 4863) | Positive FH (n= 1262) | p-value* | |
|---|---|---|---|
|
| |||
| Characteristics | |||
| Age, mean ± SD | 62 ± 10 | 62 ± 10 | 0.73 |
| Gender, n (%) | <0.001 | ||
| Male | 2411 (50) | 505 (40) | |
| Female | 2452 (50) | 757 (60) | |
| Race/Ethnicity, n (%) | <0.001 | ||
| White | 1884 (39) | 547 (43) | |
| Chinese American | 685 (14) | 39 (3) | |
| Black | 1239 (26) | 398 (32) | |
| Hispanic | 1055 (22) | 278 (22) | |
| BMI (kg/m2), mean ± SD | 28 ± 5 | 29 ± 6 | <0.001 |
| LDL-C (mg/dL), mean ± SD | 117 ± 31 | 118 ± 31 | 0.30 |
| HDL-C (mg/dL), mean ± SD | 51 ± 15 | 52 ± 15 | 0.21 |
| HTN, n (%) | 2065 (43) | 627 (50) | <0.001 |
| Diabetes Mellitus, n (%) | 478 (10) | 174 (14) | <0.001 |
| Lipid-lowering medication use, n (%) | 747 (15) | 245 (19) | <0.001 |
| Cigarette smoking, n (%) | 0.004 | ||
| Never | 2500 (52) | 596 (47) | |
| Former | 1773 (37) | 475 (38) | |
| Current | 577 (12) | 188 (15) | |
| Median CAC, Agatston Units (IQR) | 0 (78) | 5 (104) | <0.001 |
| Mean CIMT (mm ± SD) | 0.86 ± 0.19 | 0.88 ± 0.19 | 0.005 |
| CAC category, n (%) | <0.001† | ||
| CAC=0 | 2545 (52) | 574 (46) | |
| CAC= 1–99 | 1222 (25) | 368 (29) | |
| CAC=100–399 | 652 (13) | 178 (14) | |
| CAC >400 | 444 (9) | 142 (11) | |
| CIMT category, n (%) | 0.007† | ||
| ≤50th percentile | 2495 (51) | 593 (47) | |
| 51–75th percentile | 1189 (24) | 332 (26) | |
| 76–90th percentile | 709 (15) | 197 (16) | |
| >90th percentile | 470 (10) | 140 (11) | |
*
p-value for continuous variables was calculated using student’s t-test and for categorical variables using chi-squared test
†
p-value was calculated using Wilcoxon ranksum test
SD – Standard Deviation
BMI - Body Mass Index
LDL-C - Low Density Lipoprotein-Cholesterol
HDL-C - High Density Lipoprotein-Cholesterol
HTN - Hypertension (defined by JNC VI Criteria)
CAC - Coronary Artery Calcification
CIMT - Carotid Intima-Media Thickness
IQR - Interquartile Range