Table 3.

Multivariable-adjusted^* hazards ratios (95% confidence interval) for the association of CAC and CIMT with hard CHD events stratified by family history of premature CHD

	Hazard Ratios (95% CI)		Hard CHD Events
	Negative FH	Positive FH	Negative FH	Positive FH
	(n= 4863)	(n= 1262)	(n=176)	(n=67)
CAC 0	1 (ref)	1 (ref)	30	13
CAC 1–99	2.35 (1.46–3.78)	1.93 (0.91–4.10)	47	18
CAC 100–399	3.54 (2.14–5.85)	3.52 (1.58–7.84)	48	18
CAC >400	4.87 (2.88–8.24)	3.85 (1.65–9.02)	51	18
p-value for interaction	0.49
CIMT ≤50th percentile	1 (ref)	1 (ref)	62	25
CIMT 51–75th percentile	0.70 (0.46–1.08)	1.02 (0.54–1.94)	35	17
CIMT 76–90th percentile	1.20 (0.79–1.84)	1.29 (0.64–2.60)	47	15
CIMT >90th percentile	0.94 (0.58–1.52)	0.87 (0.38–1.96)	32	10
p-value for interaction	0.51
ln (CAC+1)	1.25 (1.17–1.35)	1.22 (1.09–1.37)
p-value for interaction	0.39
Continuous CIMT	1.30 (0.59–2.90)	1.20 (0.35–4.13)
p-value for interaction	0.60

^*Adjusted for age, sex, race, MESA site, cigarette smoking, hypertension, diabetes mellitus, BMI, LDL-C, HDL-C, cholesterol lowering medications

Continuous CAC units are log-transformed Agatston Units, continuous CIMT units are per millimeter change in thickness

CHD – coronary heart disease

FH – family history of premature coronary heart disease

CAC – coronary artery calcium

CIMT – carotid intima-media thickness

BMI – body mass index

LDL-C – low density lipoprotein-cholesterol

HDL-C - high density lipoprotein-cholesterol