Table 3.
Factors predictive of relapse in IBD (adapted from Torres et al21). Note: only factors identified through multivariable analysis across different studies are presented in this table.
| Factors predictive of relapse |
|---|
| Reflective of disease activity at de-escalation or during follow-up |
| • Elevated inflammatory markers (elevated leukocyte count,34, 41 elevated CRP,24, 31, 34 escalation,51, 52 elevated FC25, 34, 41 |
| • Laboratorial markers suggestive of ongoing inflammation (low hemoglobin)34 |
| • Absence of mucosal healing24, 34 |
| Factors reflective of disease poor prognostic features |
| • Smoking29, 31 |
| • Perianal disease29 |
| • Disease location (ileocolonic disease35; colonic versus ileal or ileocolonic disease46) |
| • Young age at diagnosis41, 42 |
| Previous disease course |
| • Prior disease course marked by higher therapeutic requirements (higher steroid use,34 prior anti-TNF course*,31, 35, 49 need for dose-escalation prior to discontinuation,31 prior immunomodulator failure29) |
| Other |
| • Male sex (HR 3.7 [1.9–7.4])34 |
| • Elevated/detectable IFX trough levels34 |
*
Identified as risk factor of relapse for UC.