Fig. 1.

Detail drawing of painful symptoms (a-b) and negative sensory signs (c-d). a and b: the painful area (ongoing cold pain) of two representative GD patients (paitents 5 and 8, respectively). c-d: the pinprick hypoalgesia in the same patients. e representative example of the sensory profile at QST at the proximal thigh (patient no. 12) (Z-score). Z-values above “0” indicate a gain, z-value below “0” a loss of sensory function, whereas z-values > ±2 rated pathological. Paradoxycal Heat Sensation (PHS) is here considered as a sign of gain of function. The other abbreviations are detailed in the text