Table 4.

Outcomes of the index tests and reference standard test, sensitivity and specificity (95% CI)

		Reference standard test
Alternative devices		Abnormal	Normal	Sensitivity	Specificity	AUC	Positive Likelihood ratio	Negative Likelihood ratio
Sural NCS (n)		95	89
NC-Stat	Abnormal	15	11	16%	88%	0.52	1.3	1.0
DPNCheck	Normal	80	78	(9 – 25)	(79 – 94)	(0.43 – 0.60)	(0.6 – 2.6)	(0.9 – 1.1)
Vibratip	Abnormal	0	0	0%	100%	0.50		1.0
	Normal	95	89	(0 – 4)	(96 – 100)	(0.41 – 0.58)	–	(1.0 – 1.0)
Sural WDT (n)		94	90
TST	Abnormal	78	16	83%	82%	0.83	4.7	0.2
	Normal	16	74	(74 – 90)	(73 – 89)	(0.76 – 0.89)	(3.0 – 7.4)	(0.1 – 0.3)
NeuroQuick	Abnormal	81	13	86%	86%	0.86	6.0	0.2
	Normal	13	77	(78 – 92)	(77 – 92)	(0.80 – 0.92)	(3.6 – 10.0)	(0.1 – 0.3)
Posterior tibial WDT (n)		75	115
Neuropad	Abnormal	42	35	56%	61%	0.59	1.5	0.7
	Normal	33	57	(44 – 67)	(51 – 72)	(0.51 – 0.67)	(1.1 – 2.1)	(0.5 – 1.0)
	Missing		23
TST	Abnormal	60	50	83%	57%	0.70	1.9	0.3
	Normal	12	65	(72 – 91)	(47 – 66)	(0.63 – 0.76)	(1.5 – 2.4)	(0.2 – 0.5)
NeuroQuick	Abnormal	67	68	93%	41%	0.67	1.6	0.2
	Normal	5	47	(85 – 98)	(32 – 50)	(0.60 – 0.74)	(1.3 – 1.9)	(0.1 – 0.4)

AUC area under the curve, NCS Nerve Conduction Studies, TST Thermal Sensibility Tester, WDT Warm Detection Thresholds