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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurochem Res. 2016 Aug 12;42(1):283–293. doi: 10.1007/s11064-016-2031-9

Fig. 7.

Fig. 7

Effect of ischemia on PARG expression and ADP-ribose (ADPR) levels in WT and CD38KO animals. a, b In sham animals the PARG expression levels are significantly lower in CD38KO animals when compared to WT mice. After the ischemic insult at 2 and 4 h of recovery (2hR and 4hR) the PARG levels are reduced when compared to sham group. *p < 0.05 when compared to WT sham, #p < 0.05 when compared to WT, &&&p < 0.001 when compared to WT sham, ANOVA followed by Student–Newman–Keuls test n = 6. c Correspondingly, the product of PARG activity, ADPR, is lower in CD38KO sham animals when compared to WT animals. Following ischemia in WT animals the ADPR levels were lower when compared to sham animals while ischemia in CD38KO animals did not cause significant changes in hippocampal ADPR levels. **p < 0.01, ***p < 0.001 when compared to sham animals, ##p < 0.01, ###p < 0.001 when compared to corresponding WT group, &&&p < 0.001 when compared to WT sham, @@@p < 0.001 when compared to WT 2hR, !!!p < 0.001 when compared to WT sham, aaap < 0.001 when compared to WT sham, ANOVA followed by Student–Newman–Keuls test, n = 6