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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurobiol Dis. 2016 Jul 15;95:102–110. doi: 10.1016/j.nbd.2016.07.018

Fig. 3.

Fig. 3

Effect of NMN on post-ischemic neurologic outcome. Treatment of animals with NMN restored spatial working memory loss induced by forebrain ischemia. (A) Y-maze arm entry alteration for vehicle and NMN (62.5 mg/kg) treated animals before and 6 days after forebrain ischemia. The NMN administration prevented the decrease in arm entry alternations, as well as the total number of arm entries (B). There was an increase in motor activity in vehicle treated post-ischemic animals (n = 10). (C) Y-maze arm entry alternation for animals treated with vehicle or NMN (62.5 mg/kg) 30 min after forebrain ischemia. NMN administration significantly prevented the decrease in arm entry alternations compared to vehicle. (D) There was a trend showing increased motor activity in vehicle treated post-ischemic animals. However, this increase was not significance. *p < 0.05 (n = 10), ANOVA followed by Tukey HSD test.