Table 3.
Patient-reported Outcome Measures - Change from Baseline (Adjusted)
| All patients | Dartmouth | UAB | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SE) | p * | Effect size † | Mean (SE) | p * | Effect size † | Mean (SE) | p * | Effect size † | |
| KCCQ | |||||||||
| Physical limitation | 13.30 (4.4) | 0.003 | 0.50 | 9.90 (6.1) | 0.11 | 0.37 | 17.90 (6.2) | 0.01 | 0.67 |
| Symptoms | 10.80 (4.3) | 0.01 | 0.44 | 5.30 (5.5) | 0.34 | 0.21 | 17.00 (6.6) | 0.01 | 0.69 |
| Social limitation | 8.40 (5.1) | 0.10 | 0.28 | 6.20 (6.7) | 0.36 | 0.21 | 11.10 (7.8) | 0.16 | 0.37 |
| Quality of life | 10.70 (4.0) | 0.009 | 0.4 | 10.40 (5.4) | 0.06 | 0.39 | 11.30 (6.2) | 0.07 | 0.42 |
| KCCQ functional status | 11.60 (4.0) | 0.005 | 0.49 | 6.90 (5.3) | 0.20 | 0.29 | 17.50 (5.8) | 0.004 | 0.74 |
| KCCQ clinical summary | 10.30 (3.9) | 0.009 | 0.44 | 7.80 (5.2) | 0.14 | 0.33 | 13.70 (5.7) | 0.02 | 0.58 |
| MSAS-HF Symptom Burden Index | −25.80 (7.1) | 0.0004 | −0.54 | −24.20 (8.0) | 0.003 | −0.50 | −25.7 (12.8) | 0.05 | −0.54 |
| HADS | |||||||||
| Anxiety | −1.00 (0.5) | 0.08 | −0.29 | −0.70 (0.6) | 0.28 | −0.20 | −1.20 (0.9) | 0.20 | −0.34 |
| Depression | −1.10 (0.6) | 0.07 | −0.28 | −0.90 (0.7) | 0.17 | −0.23 | −1.20 (1.1) | 0.28 | −0.31 |
| PROMIS | |||||||||
| Global Physical Health T score | 2.70 (1.5) | 0.08 | 0.32 | 1.50 (2.0) | 0.47 | 0.18 | 3.80 (2.0) | 0.07 | 0.46 |
| Global Mental Health T score | 3.00 (1.4) | 0.04 | 0.36 | 1.90 (1.8) | 0.30 | 0.23 | 4.40 (2.2) | 0.05 | 0.53 |
| PACIC | |||||||||
| Patient activation | 0.20 (0.2) | 0.26 | 0.17 | 0.20 (0.2) | 0.35 | 0.17 | 0 (0.3) | 0.95 | 0 |
| Decision support | 0.30 (0.2) | 0.10 | 0.30 | 0.20 (0.2) | 0.45 | 0.2 | 0.30 (0.3) | 0.23 | 0.30 |
| Goal setting | 0.30 (0.2) | 0.09 | 0.29 | 0.30 (0.2) | 0.25 | 0.29 | 0.20 (0.2) | 0.48 | 0.20 |
| Problem solving | 0.30 (0.2) | 0.14 | 0.27 | 0.20 (0.2) | 0.29 | 0.18 | 0.20 (0.3) | 0.59 | 0.18 |
| Care Coordination | 0 (0.2) | 0.92 | 0 | −0.10 (0.2) | 0.61 | −0.09 | 0.10 (0.3) | 0.80 | 0.09 |
| PACIC Summary Score | 0.20 (0.1) | 0.14 | 0.23 | 0.10 (0.2) | 0.42 | 0.11 | 0.10 (0.2) | 0.50 | 0.11 |
Abbreviations: SE standard error, KCCQ Kansas City Cardiomyopathy Questionnaire, MSAS-HF Memorial Symptom Assessment Scale-Heart Failure, HADS Hospital Anxiety and Depression Scale, PROMIS Patient Reported Outcomes Measurement Information System, PACIC Patient Assessment of Chronic Illness Care. All change from baseline estimates were adjusted for measures associated with attrition (e.g. religious preference, baseline PACIC-Patient Activation subscale and SHFM 1-year survival probability)
* p-values from t-test or Fisher’s exact tests, as appropriate
†Effect size: Cohen’s d or d-equivalent; small: d ~ 0.2, medium d ~ 0.5, large d ~ 0.8