Skip to main content
. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Epidemiology. 2017 Sep;28(5):667–674. doi: 10.1097/EDE.0000000000000685

Table 3.

Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer by menopausal status and age at diagnosis according to F2-Isoprostane and 15-F2t-Isoprostane metabolite concentrations categorized at the approximate 25th, 50th, 75th, and 90th percentiles.

F2-Isoprostane (ng/mgCr) N Cases Minimally adjusted model, OR (95% CI)a Fully adjusted model, OR (95% CI)b 15-F2t-Isoprostane metabolite (ng/mgCr) N Cases Minimally adjusted model, OR (95% CI)a Fully adjusted model, OR (95% CI)b
Premenopausal
<1.01 87 1.0 (ref) 1.0 (ref) <0.53 115 1.0 (ref) 1.00 (ref)
1.01–1.38 83 0.94 (0.66, 1.3) 0.98 (0.68, 1.4) 0.53–0.68 87 0.81 (0.57, 1.2) 0.82 (0.57, 1.2)
1.39–1.95 101 1.2 (0.86, 1.7) 1.4 (0.94, 2.0) 0.69–0.96 82 0.70 (0.49, 1.0) 0.72 (0.50, 1.1)
1.96–2.93 55 0.98 (0.64, 1.5) 1.1 (0.71, 1.8) 0.97–1.27 44 0.69 (0.45, 1.1) 0.76 (0.47, 1.2)
≥2.94 27 0.87 (0.51, 1.5) 1.1 (0.60, 1.9) ≥1.28 25 0.51 (0.30, 0.86) 0.59 (0.34, 1.0)
Ptrend=0.7 Ptrend=0.7 Ptrend=0.006 Ptrend=0.05
Postmenopausal
<1.01 15 1.00 (ref) 1.00 (ref) <0.53 18 1.0 (ref) 1.0 (ref)
1.01–1.38 27 2.2 (0.98, 4.9) 2.1 (0.88, 4.9) 0.53–0.68 22 1.1 (0.54, 2.3) 1.0 (0.47, 2.2)
1.39–1.95 22 1.5 (0.65, 3.3) 1.4 (0.57, 3.3) 0.69–0.96 28 1.7 (0.81, 3.8) 2.0 (0.84, 4.6)
1.96–2.93 21 3.3 (1.4, 8.2) 3.0 (1.1, 8.0) 0.97–1.27 20 1.6 (0.74, 3.5) 1.5 (0.60, 3.7)
≥2.94 12 1.7 (0.66, 4.6) 1.4 (0.49, 4.2) ≥1.28 9 1.4 (0.52, 3.8) 1.2 (0.37, 4.0)
Ptrend=0.2 Ptrend=0.4 Ptrend=0.3 Ptrend=0.5
35–45 years
<1.01 18 1.0 (ref) 1.0 (ref) <0.53 32 1.0 (ref) 1.0 (ref)
1.01–1.38 25 0.74 (0.34, 1.6) 0.54 (0.21, 1.4) 0.53–0.68 19 0.58 (0.27, 1.3) 0.39 (0.15, 1.0)
1.39–1.95 22 0.70 (0.31, 1.6) 0.61 (0.23, 1.6) 0.69–0.96 18 0.39 (0.18, 0.85) 0.24 (0.09, 0.63)
≥1.96 17 0.42 (0.17, 1.0) 0.31 (0.10, 0.92) ≥0.97 13 0.26 (0.12, 0.58) 0.15 (0.06, 0.42)
Ptrend=0.05 Ptrend=0.06 Ptrend=0.001 Ptrend<0.001
46–50 years
<1.01 43 1.0 (ref) 1.0 (ref) <0.53 50 1.0 (ref) 1.0 (ref)
1.01–1.38 38 0.89 (0.53, 1.5) 0.94 (0.54, 1.6) 0.53–0.68 46 0.96 (0.58, 1.6) 0.97 (0.58, 1.6)
1.39–1.95 50 1.4 (0.85, 2.3) 1.5 (0.84, 2.5) 0.69–0.96 43 0.83 (0.50, 1.4) 0.80 (0.46, 1.4)
≥1.96 42 1.3 (0.72, 2.2) 1.5 (0.78, 2.8) ≥0.97 34 0.77 (0.45, 1.3) 0.80 (0.43, 1.5)
Ptrend=0.3 Ptrend=0.1 Ptrend=0.3 Ptrend=0.4
51–60 years
<1.01 44 1.0 (ref) 1.0 (ref) <0.53 54 1.0 (ref) 1.0 (ref)
1.01–1.38 48 1.3 (0.81, 2.2) 1.4 (0.84, 2.4) 0.53–0.68 46 0.83 (0.52, 1.3) 0.83 (0.51, 1.4)
1.39–1.95 53 1.3 (0.77, 2.1) 1.4 (0.81, 2.3) 0.69–0.96 50 1.0 (0.63, 1.7) 1.1 (0.67, 1.9)
≥1.96 56 1.3 (0.82, 2.2) 1.6 (0.91, 2.7) ≥0.97 51 1.0 (0.63, 1.7) 1.2 (0.68, 2.1)
Ptrend=0.4 Ptrend=0.2 Ptrend=0.7 Ptrend=0.3
a

Adjusted for age and enrollment year

b

Adjusted for age, enrollment year, fruits/vegetable servings per day, BMI, waist circumference, smoking status, physical activity, income, alcohol, vitamin C supplements, vitamin E supplements