Figure 2. Decreased modular interferon response at days 3 and 14.

Blood transcriptional responsiveness to malaria vaccination was determined at the modular level in subjects 3 and 14 days following administration of the third dose of RTS,S. A. As is the case of Figure 1 the percentage of responsive transcripts was determined for each module (co-clustered gene set) and represented by a colored spot on a heatmap where modules are arranged in rows and samples in columns. Increases in transcript abundance compared to baseline pre-third vaccine sample are shown in red and decreases in transcript abundance in blue. Modules and samples are arranged by hierarchical clustering based on patterns of module responsiveness. B. Similar description as in A, this time applied to day 14 data. C. Responsiveness of module M1.2 at days 3 and 14 post vaccination are represented on a plot showing also differences between the protected and non-protected groups.