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. 2017 Jul 18;4:919. Originally published 2015 Sep 29. [Version 2] doi: 10.12688/f1000research.7093.2

Figure 5. Detection of antigen-specific IgE in serum samples of children who received the RTS,S vaccine or comparator vaccines.

Figure 5.

IgE levels are shown for 23 children who received the comparator vaccines (11 non-protected (NP) and 12 protected(P)/Non-exposed (NE) subjects) and 44 children who received the RTS,S vaccine (22 non-protected and 22 protected/NT subjects). Blood samples were collected from children at baseline before receiving the vaccine (pre-vaccination) and 1 month after the 3 rd dose of vaccination (post-vaccination). The children who developed malaria infection during follow up were classified in the “Non-protected” group and those who did not, were classified in the “Protected/NE” group. A) comparison of levels of CSP-, CTerm-, NANP-specific IgE (dilution 1:30), and MSP2-, MSP3-, EXP1-specific IgE (dilution 1: 2,430) in serum samples of comparator vaccine control or RTS,S vaccine groups. Red, green and brown boxes identify the samples that were over the higher limit of quantification. B) Antigen-specific IgE in serum samples of RTS,S vaccinated group identified by the red, green and brown boxes in panel A which were re-run at a higher dilution (1: 21,870). C) Comparison of levels of MSP2-, MSP3- and EXP1-specific IgE in serum samples of comparator vaccine control or RTS,S vaccine; blue represented “Protected/NE” and orange represented “Non-protected”. The results represent means ± standard errors (SE). Statistical significance was determined using Wilcoxon signed-rank test or Mann Whitney test; ns, not significant, * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001. The horizontal lines indicate mean ± standard errors (SE).