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. Author manuscript; available in PMC: 2018 Jul 20.
Published in final edited form as: Mol Cell. 2017 Jul 6;67(2):252–265.e6. doi: 10.1016/j.molcel.2017.06.008

Figure 7. Acetyl-CoA production by ATP-citrate lyase facilitates homologous recombination during S/G2 phases of the cell cycle.

Figure 7

ACLY is phosphorylated at Ser455 within the nucleus in response to DNA damage in a cell cycle-dependent manner. This enables appropriate spatial and temporal control of acetyl-CoA production, enabling histone acetylation at DSB sites, BRCA1 recruitment, and DNA repair by HR.