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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Cell Rep. 2017 Aug 29;20(9):2116–2130. doi: 10.1016/j.celrep.2017.08.014

FIGURE 3. Analysis of Aplnr KO and Aplnr;Apela double mutant embryos.

FIGURE 3

(A) Aplnr KO embryos at E9.5 isolated from homozygous KO males crossed to heterozygous or homozygous KO females. (B) Aplnr KO embryos were recovered from heterozygous intercrosses in expected Mendelian ratios at E9.5 (n=75). Survival of adult Aplnr KO mice was significantly reduced. (C) Recovery of Aplnr;Apela double mutant genotypes at E9.5 from double heterozygous intercrosses. (D–E) Aplnr;Apela (NEO-IN) double mutants. The Apela null phenotype was observed among double heterozygous embryos (D). Aplnr;Apela double KO embryos not shown were morphologically normal.