Table 2.
Characteristic | Category | Deceased | Survived | HR (crude)a,b | 95%-CI (crude)a,b | p-valueb | HR (adjusted)a,c | 95%-CI (adjusted)a,c | p-valuec |
---|---|---|---|---|---|---|---|---|---|
Therapy | TL + a(C)RT | 74 (77.9) | 12 (100) | 1 | - | - | 1 | - | - |
CRT | 13 (13.7) | 0 (0.0) | 3.0 | (1.6, 5.6) | 0.0004 | 2.0 | (1.04, 3.7) | 0.0369 | |
RT | 8 (8.4) | 0 (0.0) | 4.2 | (2.0, 8.9) | 0.0002 | 4.6 | (2.1, 9.8) | 0.0001 | |
Aged | (10 year units) | 1.3 | (1.1, 1.6) | 0.0085 | 1.4 | (1.1, 1.7) | 0.0014 | ||
Recurrences | No | 74 (77.9) | 12 (100) | 1 | - | - | 1 | - | - |
Yes | 21 (22.1) | 0 (0.0) | 8.5 | (5.1, 14.7) | <.0001 | 7.3 | (4.1, 12.9) | <.0001 | |
N-stage | N0,N1 | 56 (58.9) | 10 (83.3) | 1 | - | - | 1 | - | - |
N2,N3 | 39 (41.1) | 2 (16.7) | 2.2 | (1.5, 3.4) | 0.0002 | 1.6 | (1.0, 2.5) | 0.0489 | |
Tumour location | glottic | 18 (18.9) | 0 (0.0) | 1 | - | - | |||
supraglottic | 34 (35.8) | 4 (33.3) | 0.75 | (0.42, 1.3) | 0.3282 | ||||
subglottic | 6 (6.3) | 2 (16.7) | 0.62 | (0.24, 1.6) | 0.3067 | ||||
transglottic | 26 (27.4) | 3 (25.0) | 0.74 | (0.40, 1.4) | 0.3300 | ||||
Unknown | 11 (11.6) | 3 (25.0) | 0.71 | (0.33, 1.5) | 0.3706 | ||||
CCIe | None | 56 (58.9) | 11 (91.7) | 1 | - | - | |||
One and more | 39 (41.1) | 1 (8.3) | 1.8 | (1.2, 2.7) | 0.0061 | ||||
2nd primary carcinoma | None | 88 (92.6) | 11 (91.7) | 1 | - | - | |||
Yes | 7 (7.4) | 1 (8.3) | 1.3 | (0.60, 2.9) | 0.4857 |
aHR: Hazard Ratio; CI: Confidence interval; bResults from univariate analysis; cResults from multivariate analysis using backward selection; dcontinuous, eCCI: Charlson Comorbidity Index