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. 2017 Sep 1;17:609. doi: 10.1186/s12885-017-3608-7

Table 2.

Univariate and multivariate Cox proportional hazard analysis results for all T4 patients (N = 107), 1998–2015

Characteristic Category Deceased Survived HR (crude)a,b 95%-CI (crude)a,b p-valueb HR (adjusted)a,c 95%-CI (adjusted)a,c p-valuec
Therapy TL + a(C)RT 74 (77.9) 12 (100) 1 - - 1 - -
CRT 13 (13.7) 0 (0.0) 3.0 (1.6, 5.6) 0.0004 2.0 (1.04, 3.7) 0.0369
RT 8 (8.4) 0 (0.0) 4.2 (2.0, 8.9) 0.0002 4.6 (2.1, 9.8) 0.0001
Aged (10 year units) 1.3 (1.1, 1.6) 0.0085 1.4 (1.1, 1.7) 0.0014
Recurrences No 74 (77.9) 12 (100) 1 - - 1 - -
Yes 21 (22.1) 0 (0.0) 8.5 (5.1, 14.7) <.0001 7.3 (4.1, 12.9) <.0001
N-stage N0,N1 56 (58.9) 10 (83.3) 1 - - 1 - -
N2,N3 39 (41.1) 2 (16.7) 2.2 (1.5, 3.4) 0.0002 1.6 (1.0, 2.5) 0.0489
Tumour location glottic 18 (18.9) 0 (0.0) 1 - -
supraglottic 34 (35.8) 4 (33.3) 0.75 (0.42, 1.3) 0.3282
subglottic 6 (6.3) 2 (16.7) 0.62 (0.24, 1.6) 0.3067
transglottic 26 (27.4) 3 (25.0) 0.74 (0.40, 1.4) 0.3300
Unknown 11 (11.6) 3 (25.0) 0.71 (0.33, 1.5) 0.3706
CCIe None 56 (58.9) 11 (91.7) 1 - -
One and more 39 (41.1) 1 (8.3) 1.8 (1.2, 2.7) 0.0061
2nd primary carcinoma None 88 (92.6) 11 (91.7) 1 - -
Yes 7 (7.4) 1 (8.3) 1.3 (0.60, 2.9) 0.4857

aHR: Hazard Ratio; CI: Confidence interval; bResults from univariate analysis; cResults from multivariate analysis using backward selection; dcontinuous, eCCI: Charlson Comorbidity Index