Table 1.
Inhibitory activity of clinically used human immunodeficiency virus-1 (HIV-1) inhibitors on porcine endogenous retrovirus (PERV).
| Type of Inhibitor | Name | Inhibition of PERV | Reference |
|---|---|---|---|
| Nucleoside reverse transcriptase inhibitors (NRTIs) | AZT (azidothymidine, also called ZDV, zidovudin) | yes | [18,19,20,21,22,25] |
| 3TC (lamivudine) | no | [18,20] | |
| d4T (stavudin) | no/yes | [18,20,22] | |
| Nucleotide reverse transcriptase inhibitors (NtRTIs) | TAV (adefovir) | yes | [22,25] |
| TDF (tenofovir) | yes | [22,25] | |
| Non-nucleoside reverse transcriptase inhibitors (NNRTIs) | EFV (efavirenz) | n.t. | [20,25] |
| ETV (etravirin) | n.t. | [20,25] | |
| NVP (nevirapin) | no | [20,25] | |
| Integrase inhibitors | RAL (raltegravir) | yes | [24,25] |
| DTG (dolutegravir) | yes | [24,25] | |
| Protease inhibitors | IDV (indinavir) | no | [18,20] |
| NLV (nelfinavir) | no | [20] | |
| SQV (saquinavir) | no | [20] | |
| RTV (ritonavir) | no | [20] | |
| APV (amprenavir) | no | [20] |
n.t., not tested.