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. 2017 Aug 9;9(8):217. doi: 10.3390/v9080217

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of the Epstein Barr virus (EBV) OriP and interacting viral and telomeric proteins. Organization of the OriP region where the family of repeats (F) and dyad symmetry (DS) regions are indicated. The enlarged region within the DS contains two EBV nuclear antigen (EBNA)1 binding sites (black box) adjacent to telomere-like sequences (red box) where EBNA1 and telomere-associated proteins bind and recruit proteins, such as Origin Recognition Complex (ORC) and MCM, that are involved in viral genome replication and maintenance. TRF1-interacting protein, TNKS, interacts with EBNA1 and regulates OriP replication.