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Model representing our current understanding of TF and 6K. (A) TF is less abundant than 6K. It is palmitoylated and traffics from the ER to the plasma membrane (PM) where it is budded into virions. TF may oligomerize and function as an ion channel. (B) 6K is found concentrated at interior membranes where it likely interacts with the viral glycoproteins. The 6K channel properties resulting from oligomerization probably affect the ER. Additionally, 6K may interact with host proteins.
