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. Author manuscript; available in PMC: 2018 Jul 20.
Published in final edited form as: Mol Cell. 2017 Jul 6;67(2):322–333.e6. doi: 10.1016/j.molcel.2017.06.007

Figure 5. RP Remodeling upon RP-CP Association.

Figure 5

(A) The side view of the p28-AAA subcomplex in the TA7 state docking onto the α-ring surface, by aligning the AAA domains in the free RP against those in the 26S in the SA state. The model predicts that p28 is subject to little or no clashes with the α-ring surface when the free RP first encounters the CP.

(B) The top view of the p28-AAA subcomplex docking onto the α-ring surface.

(C) The top view of the AAA hexamer on the α-ring surface in the 26S structure for comparison. The structure of p28-AAA subcomplex is superposed as a transparent cartoon.

(D) The side view of the pseudo-atomic model of the free RP in the TA7 state docking onto the α-ring surface, with the same alignment as used in panel (A).

(E) The side view of the 26S in the SA state, in the same orientation of the CP, showing that a large RP rotation accompanying the release of p28.