Figure 1.

CFC memory is insensitive to MK-801 between the parameters that induce reconsolidation and extinction. Animals were subjected to Contextual Fear Conditioning and 2 d later, to a (A) context reexposure session of 3, 5, 10, 20, or 30-min. Immediately after, they received i.p. MK-801 or saline. Memory was assessed on the following day in a (B) test session. MK-801 had a significant effect when administered after 3 or 30 min, but no effect upon the intermediate conditions of 5, 10, and 20 min. There were no preexisting differences between groups during the start (first 3 min) or the end (last 3 min, or last 2 min in the 5-min condition) of the reexposure sessions in any condition. Data presented as mean + SEM. (*) P < 0.05 (MK-801 × Control). n = 14 (Sal-MK/3 min), 13 (Sal/5 min), 7 (MK/5 min), 8 (Sal-MK/10–20 min), 20 (Sal/30 min), and 22 (MK/30 min).