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. 2017 Aug 16;14(8):921. doi: 10.3390/ijerph14080921

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The CpG dinucleotides contained TFBSs in the investigated sequence for methylation of ERCC3 promoterregion. (B) The TFBSs and enrichment of H3K4me3 and H3K27ac modification in ERCC3 promoter region in human embryonic stem cells (hESC) (Green area) and in K562 cells (Blue area). Red triangle indicated CpG unit. * TFBSs by JASPAR CORE Database (http://jaspar.genereg.net/). ** HMR Conserved TFBSs by Transfac Matrix Database (v.7.0) (https://genome.ucsc.edu/). TFAP2A: transcription factors activating enhancer binding protein 2 alpha, MZF1: myeloid zinc finger-1, TSS: transcriptional start site, TFBSs: transcription factor binding sites.