Table 1.
Associations between benzene exposure and promoter DNA methylation in ERCC3.
| CpG Unit a | In Relation to TSS | Control (n = 24) Mean ± SD (Cm%) | Exposure (n = 76) Mean ± SD (Cm%) | Beta | SE | p Value | FDR Value |
|---|---|---|---|---|---|---|---|
| 1 | −62 bp | 3.04 ± 2.69 | 3.87 ± 3.94 | 0.07 | 0.19 | 0.725 | 0.725 |
| 2–4 | −43 bp | 4.92 ± 1.53 | 5.86 ± 2.77 | 0.19 | 0.09 | 0.032 * | 0.176 |
| 5 | −36 bp | 1.38 ± 1.66 | 2.51 ± 3.44 | 0.32 | 0.18 | 0.082 | 0.226 |
| 6 | −19 bp | 1.21 ± 2.02 | 2.74 ± 3.90 | 0.28 | 0.20 | 0.153 | 0.281 |
| 7 | −9 bp | 4.54 ± 3.11 | 4.69 ± 4.03 | 0.09 | 0.18 | 0.626 | 0.689 |
| 9–10 | +30 bp | 6.96 ± 3.13 | 7.74 ± 3.49 | 0.15 | 0.09 | 0.107 | 0.235 |
| 11 | +56 bp | 1.15 ± 1.68 | 2.81 ± 4.36 | 0.21 | 0.38 | 0.576 | 0.689 |
| 13–14 | +71 bp | 6.46 ± 4.96 | 7.47 ± 5.50 | 0.19 | 0.19 | 0.317 | 0.436 |
| 15–16 | +87 bp | 1.54 ± 2.06 | 3.04 ± 3.85 | 0.39 | 0.20 | 0.059 | 0.216 |
| 17–18 | +99 bp | 6.79 ± 2.50 | 8.45 ± 4.09 | 0.24 | 0.11 | 0.024 * | 0.176 |
a data missing due to low signal/noise ratio by MALDI-TOF MS. Cm%: methylated cytosine percentage; FDR: false discovery rate. Linear regression models were adjusted for sex, age, alcohol drinking,smoking status, body mass index, and percentage of lymphocytes, neutrophils and monocytes. * p value < 0.05.