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. 2017 Sep;27(9):1573–1588. doi: 10.1101/gr.221218.117

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© 2017 Shrestha et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Summary of driver genes prioritized by HIT'nDRIVE. (A) Distribution of predicted driver genes in cancer genes databases. The CGC database contains genes for which mutations have been causally implicated in cancer. Genes curated in the CGC database represent likely drivers of cancer. COSMIC is a comprehensive database of somatic mutations that have been reported in different cancers. However, every gene present in COSMIC database may not represent drivers of cancer. (B) Distribution of driver genes in druggable genes databases. Actionable genes in cancer therapy were derived from the TARGET database. List of druggable genes were extracted from DGI database. (A,B) The numbers in the panel represent the number of genes in respective categories. (C) Distribution of patient druggability. Patient druggability was accessed using information in the TARGET and DGI databases. The numbers in the panel represent the number of patients in respective categories.