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. 2017 Sep;27(9):1573–1588. doi: 10.1101/gr.221218.117

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© 2017 Shrestha et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — BRCA subtype classification using driver modules. (A) Performance accuracy of classifying different subtypes for breast cancer using the activity score of subtype-specific driver modules as features in three distinct data sets. (B) Box plot comparing subtype-specific driver-seeded modules and driver-free modules with respect to three distinct measures: log-rank test P-value, hazard ratio (HR), and concordance index (c-index). (C) A BRCA subtype-specific driver module (BASAL-02) seeded by NCOA3 that distinguished the Basal subtype from rest of the BRCA subtypes. (D) Activity score of the BASAL-02 module across different BRCA subtypes. (E) Kaplan-Meier plot showing the significant association of the BASAL-02 module with patients’ clinical outcome in the three data sets considered.