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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neuron. 2016 Jul 7;91(3):561–573. doi: 10.1016/j.neuron.2016.06.017

Figure 3. The Effect of Pharmacological Agents and Arc cis Elements on Glutamate-Induced De Novo Translation of Arc.

Figure 3

The number of dendritic Gluc puncta before (58–97 frames) and after (128–167 frames) glutamate. Indicated drugs or vehicles were added to cultures 5–30 min before addition of CTZ (16–41 min before addition of glutamate) and continuing to the end. (A–C) Each gray line represents an individual cell and red line represents the average of all cells (mean ± SEM).

(A) Control. p = 0.015 (N = 17).

(B) Emetine. p = 0.176 (N = 9).

(C) Anisomycin. p = 0.131 (N = 8).

(D and E) Population responses to drugs administered in (D) water vehicle (p = 0.006; N = 17, 7, and 9, respectively, Kruskal-Wallis test) and (E) DMSO vehicle (p = 0.034; N = 9, 9, and 9, respectively, Kruskal-Wallis test).