Figure 2.

Chronic pain-induced anxiety-like behavior displays large individual variance. (a) Traces of locomotor activity in a sham and a PNL mouse in an open field test (OFT). (b) Averaged group data of the time spent in the central zone (central time) in sham (n = 18) and PNL (n = 26) mice. (c) Individual data of the same mice groups as in (b), with the PNL mice divided into vulnerable (vul/PNL) group (mice with central times below the group average of central time in sham mice (109.0 s, n = 18) indicated by the dashed line, n = 20) and resistant (res/PNL) group (mice with central times above the average, n = 6). (d) Individual data of total distance traveled in the three mouse groups. Behaviors of mechanical (e) and thermal (f) pain responses in the three mouse groups. *p < 0.05. ***p < 0.001.

PNL: partial sciatic nerve ligation.