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Maximal changes of systolic blood pressure (SBP) (A), mean arterial pressure (MAP) (B), and heart rate (HR) (C) in response to infusion of angiotensin II (Ang II 300 ng/kg) and Ang II+ Losartan (Los; 10 mg/kg). Data are expressed as mean ± SEM (n= 6 in each group). One way ANOVA with post hoc test used for statistical analysis. *** p<0.001 compared to control group, +++ p<0.001 compared to Ang II 300 group and # p<0.05 and ## p<0.01 compared to control group
